Wikipedia on Regulate

The third verse is more expository, with Warren and Nate explaining their G Funk musical style. Nate displays his bravado by claiming that anyone with the same amount of knowledge as himself would not even attempt to approach his level of lyrical mastery. He also notes that if any third party smokes like he does, they would find themselves in a state of intoxication every day. From Nate's other works, it can be inferred that the substance being smoked is marijuana. Nate concludes his delineation of the night by issuing a vague threat to "busters," suggesting that he and Warren will further "regulate" any potential situations in the future (presumably by Nate engaging their enemies in a battle of small arms fire, while Warren watches and shares credit afterwards).